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Tianmeng Xu, MSc

Research Technician

Before joining the Brandon lab, I finished my M.Sc. degree under the supervision of Dr. Alexey Pshezhetsky in McGill University’s Integrated Program of Neuroscience. I was working on a gene therapy project for which I received two scholarships from the Canadian MPS Society. My work focuses on developing a medical approach that treats the progressive neurological disorder Mucopolysaccharidosis III type C (MPS IIIC or Sanfilippo Syndrome). While working in Dr. Pshezhetsky’s lab, we overexpressed the deficient enzyme in microglial cells through transplantation of hematopoietic stem cells transduced with a recombinant lentivirus-based vector carrying the missing enzyme in MPS IIIC. As a part of my master’s project, I also cultured hiPSC-derived neurons to study synaptic-specific markers, to test for disease markers, and for in vitro drug testing. I joined the Brandon lab in the fall of 2022 to learn more about memory, spatial navigation, and the different techniques used in Neuroscience.

Pan, X., Taherzadeh, M. Bose, P. Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT. J Exp Med. 2022 Aug 1;219(8):e20211860. doi: 10.1084/jem.20211860.

Published Papers

  • 2023 McGill University Montreal, QC Neuroscience Master of Science

  • 2020 McGill University Montreal, QC Neuroscience Bachelor of Science

Education

Awards, Recognition

  • 2020 - Canadian MPS Society

  • 2019 - Canadian MPS Society

Tianmeng Xu, MSc

Research Technician

  • 2023 McGill University Montreal, QC Neuroscience Master of Science

  • 2020 McGill University Montreal, QC Neuroscience Bachelor of Science

Education

Awards, Recognition

  • 2020 - Canadian MPS Society

  • 2019 - Canadian MPS Society

Pan, X., Taherzadeh, M. Bose, P. Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT. J Exp Med. 2022 Aug 1;219(8):e20211860. doi: 10.1084/jem.20211860.

Published Papers

Before joining the Brandon lab, I finished my M.Sc. degree under the supervision of Dr. Alexey Pshezhetsky in McGill University’s Integrated Program of Neuroscience. I was working on a gene therapy project for which I received two scholarships from the Canadian MPS Society. My work focuses on developing a medical approach that treats the progressive neurological disorder Mucopolysaccharidosis III type C (MPS IIIC or Sanfilippo Syndrome). While working in Dr. Pshezhetsky’s lab, we overexpressed the deficient enzyme in microglial cells through transplantation of hematopoietic stem cells transduced with a recombinant lentivirus-based vector carrying the missing enzyme in MPS IIIC. As a part of my master’s project, I also cultured hiPSC-derived neurons to study synaptic-specific markers, to test for disease markers, and for in vitro drug testing. I joined the Brandon lab in the fall of 2022 to learn more about memory, spatial navigation, and the different techniques used in Neuroscience.
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