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Computational modeling helps the Brandon Lab interpret data, generate predictions, and test mechanistic hypotheses about memory and navigation circuits. Models are developed to remain closely tied to experimental observations, allowing theory and data to inform one another. This work is especially important when asking how circuit-level interactions give rise to stable yet flexible cognitive representations.

Description

Computational Modeling

Technique

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Predictive Coding of Reward in the Hippocampus

Population dynamics of head-direction neurons during drift and reorientation

The representation of context in mouse hippocampus is preserved despite neural drift

A zero-inflated gamma model for post deconvolved calcium imaging traces

Head direction is coded more strongly than movement direction in a population of entorhinal neurons

Segregation of cortical head direction cell assemblies on alternating theta cycles

A model combining oscillations and attractor dynamics for generation of grid cell firing

Cellular dynamical mechanisms for encoding the time and place of events along spatiotemporal trajectories in episodic memory

A phase code for memory could arise from circuit mechanisms in entorhinal cortex

Linking cellular mechanisms to behavior: entorhinal persistent spiking and membrane potential oscillations may underlie path integration, grid cell firing, and episodic memory

Computational Modeling is used in these papers

Computational modeling helps the Brandon Lab interpret data, generate predictions, and test mechanistic hypotheses about memory and navigation circuits. Models are developed to remain closely tied to experimental observations, allowing theory and data to inform one another. This work is especially important when asking how circuit-level interactions give rise to stable yet flexible cognitive representations.

Description

Computational Modeling

Technique

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