In vivo electrophysiology provides high temporal resolution recordings of neural activity during natural behavior. In the Brandon Lab, this method is used to study precise spike timing, coordination across circuits, and the fast dynamics that underlie memory and navigation. It complements imaging approaches by revealing temporal structure that is essential for understanding circuit computation.
Description
In Vivo Electrophysiology
Technique
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex
Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues
Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies
The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity
New and Distinct Hippocampal Place Codes Are Generated in a New Environment during Septal Inactivation
In Vivo Electrophysiology is used in these papers
In vivo electrophysiology provides high temporal resolution recordings of neural activity during natural behavior. In the Brandon Lab, this method is used to study precise spike timing, coordination across circuits, and the fast dynamics that underlie memory and navigation. It complements imaging approaches by revealing temporal structure that is essential for understanding circuit computation.
Description
