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Transgenic mouse models are essential for studying cell-type-specific circuit function and disease-related mechanisms. The Brandon Lab uses both targeted genetic lines and disease models to dissect the neural basis of cognition and its disruption. These tools allow experiments that would not be possible with anatomy or behavior alone.
Description
Technique
Transgenic Mouse Models
Medial Entorhinal VIP-expressing interneurons receive input from Thalamic Anterior Dorsal Nucleus and are critical for spatial memory
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex
Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues
Transgenic Mouse Models is used in these papers
Transgenic mouse models are essential for studying cell-type-specific circuit function and disease-related mechanisms. The Brandon Lab uses both targeted genetic lines and disease models to dissect the neural basis of cognition and its disruption. These tools allow experiments that would not be possible with anatomy or behavior alone.
Description
Technique
Transgenic Mouse Models
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